Zodon 25 mg/ml Oral Solution for Cats and Dogs

What is Zodon 25 mg/ml Oral Solution?

Zodon 25 mg/ml oral solution is a veterinary antibiotic belonging to the lincosamide class. Its active ingredient is clindamycin — a broad-spectrum antibiotic effective against a range of gram-positive bacteria and anaerobes. Each ml of Zodon 25 mg/ml contains 25 mg of clindamycin (equivalent to 27.15 mg clindamycin hydrochloride). The solution is clear and amber-coloured, flavoured for easier administration.

Zodon is produced by Ceva Santé Animale, France — one of the world’s leading veterinary pharmaceutical companies.

Active Ingredient & Composition

• Active substance: Clindamycin – 25 mg/ml (as clindamycin hydrochloride 27.15 mg)
• Excipient: Ethanol 96% (E1510) – 72 mg/ml

Clindamycin after oral administration is almost completely absorbed from the gastrointestinal tract. After a dose of 11 mg/kg, peak plasma concentrations of approximately 8 µg/ml are reached within one hour. The elimination half-life is approximately 4 hours. Around 70% is excreted in faeces and 30% in urine.

Therapeutic Indications

Zodon 25 mg/ml oral solution is indicated for the treatment of infections caused by clindamycin-susceptible bacteria in the following species:

🐱 Cats

• Treatment of infected wounds and abscesses caused by clindamycin-susceptible Staphylococcus spp. and Streptococcus spp.

🐶 Dogs

• Treatment of infected wounds, abscesses and oral/dental infections caused by or associated with clindamycin-susceptible Staphylococcus spp., Streptococcus spp., Bacteroides spp., Fusobacterium necrophorum, and Clostridium perfringens
• Adjunctive treatment during mechanical or surgical periodontal therapy for infections of the gingival and periodontal tissues
• Treatment of osteomyelitis caused by Staphylococcus aureus

Dosage & Administration – Zodon 25 mg/ml

For oral use only. A graduated 3 ml syringe is provided to ensure accurate dosing. The flavoured solution can be administered directly into the animal’s mouth or added to a small amount of food.

Cats – Infected Wounds & Abscesses

• 11 mg clindamycin per kg body weight every 24 hours, OR
• 5.5 mg/kg every 12 hours
• Duration: 7 to 10 days
• ⚠️ Discontinue treatment if no therapeutic effect is observed after 4 days

Dogs – Infected Wounds, Abscesses & Dental Infections

• 11 mg clindamycin per kg body weight every 24 hours, OR
• 5.5 mg/kg every 12 hours
• Duration: 7 to 10 days
• ⚠️ Discontinue treatment if no therapeutic effect is observed after 4 days

Dogs – Osteomyelitis (Bone Infections)

• 11 mg clindamycin per kg body weight every 12 hours
• Duration: minimum 28 days
• ⚠️ Discontinue treatment if no therapeutic effect is observed after 14 days

Contraindications

Do NOT use Zodon oral solution in the following species — clindamycin may cause severe and potentially fatal gastrointestinal disturbances in:

• Hamsters
• Guinea pigs
• Rabbits
• Chinchillas
• Horses
• Ruminants (cattle, sheep, goats)

Also do not use in animals with known hypersensitivity to clindamycin, lincomycin, or any of the excipients.

Adverse Reactions

Vomiting and diarrhoea have been reported very rarely. In case of prolonged therapy (one month or more), periodic monitoring of liver and renal function and blood counts is recommended.

Drug Interactions

Important interactions to be aware of when using Zodon:

• Chloramphenicol / Macrolides (e.g. erythromycin): Do not use simultaneously — antagonistic effects may occur
• Aminoglycosides (e.g. gentamicin): Simultaneous use carries a risk of acute renal failure
• Cyclosporin: Clindamycin may reduce plasma levels of this immunosuppressant
• Neuromuscular blocking agents: Clindamycin has intrinsic neuromuscular blocking activity — use with caution
• Antacids (aluminium salts, kaolin): May reduce absorption — administer at least 2 hours before clindamycin

Storage & Shelf Life

• Store at a temperature below 30°C
• Keep out of reach of children
• Shelf life as packaged: 3 years (21 months per some labelling)
• Shelf life after first opening: 28 days

Manufacturer

Ceva Santé Animale, France