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Tiamulin is a semisynthetic derivative of the naturally occurring diterpene antibiotic pleuromutilin with bacteriostatic action against Gram-positive bacteria (e.g. staphylococci, streptococci, Arcanobacterium pyogenes), Mycoplasma spp. spirochetes (Brachyspira hyodysenteriae, B. pilosicoli) and some Gram-negative bacilli such as Pasteurella spp. Bacteroides spp. Actinobacillus (Haemophilus) spp. Fusobacterium necrophorum, Klebsiella pneumoniae and Lawsonia intracellularis. Tiamulin distributes widely in tissues, including the colon and the lungs, and acts by binding to the 50S ribosomal subunit, thereby inhibiting bacterial protein synthesis.
Tiamulin is indicated for gastrointestinal and respiratory infections caused by tiamulin sensitive micro-organisms, including swine dysentery caused by Brachyspira spp. and complicated by Fusobacterium and Bacteroides spp. enzootic pneumonia complex of pigs and mycoplasmal arthritis in swine.
Do not administer in case of hypersensitivity to Tiamulin or other pleuromutilins. Animals should not receive products containing polyether ionophores such as monensin, narasin or salinomycin during or for at least seven days before or after treatment with Tiamulin.
Erythema or mild oedema of the skin may occur in pigs following intramuscular administration of Tiamulin. When polyether ionophores such as monensin, narasin and salinomycin are administered during or at least seven days before or after treatment with Tiamulin, severe growth depression or even death may occur.
For intramuscular administration. Do not administer more than 3.5 ml per injection site.
Swine: 1 ml per 5 – 10 kg body weight for 3 days.
– For meat: 14 days.