Zoletil 100 / 50


In one vial with powder: tiletamine HCl 250 mg, zolazepam base 250 mg.
In the vial with solvent: sterilized water for injection 5 ml. Solubility 50 mg / ml.

Pharmacological Properties:
Zoletil is a major injectable anesthetic. Tiletamine is a dissociative anesthetic. Zolazepam is a sedative, anxiolytic, and muscle relaxant. It enhances the tiletamine depression of the central nervous system. It also prevents seizures due to tiletamine and improves muscle relaxation and recovery after anesthesia. Zoletil 100 produces a state of unconsciousness, which has been described as dissociative because it seems to interrupt the associative pathways to the brain selectively. Depending on the animal species, analgesia lasts after the effect of the sedative has subsided. Pharyngeal and laryngeal reflexes remain intact. Cranial nerves and spinal reflexes remain intact. Therefore, the animal’s eyes remain open, and it can swallow, move its tongue, chew, blink, and limb during anesthesia.

The actions of Zoletil can be summarized as follows:

  • Catatonia: rapid, without excitement, followed by muscle relaxation.
  • Analgesia: Immediate superficial pain relief, moderate visceral analgesia.
  • Surgical anesthesia: With muscle relaxation, resistance to laryngeal, pharyngeal, and palpebral reflexes, without depression of the respiratory center, possible salivation.

Introduction to anaesthesia before inhalation anesthesia or as the sole anaesthetic for a wide variety of diagnostic and short-term surgical procedures. With greater tolerability from cats, dogs, and many wild and exotic animals.

Premedication Atropine Sulfate:

  • Dogs-0.1 mg / kg subcutaneously, 15 min. before injection of Zoletil.
  • Cats – 0.05 mg / kg from SC, 15 min. before injection of Zoletil.

Mix the contents of the vial with the solvent immediately before use.


  • For intramuscular administration – loss of balance retention reflex after 3-6 minutes.
  • For intravenous administration – loss of balance retention reflex in less than 1 min.


  • Intramuscularly in dogs – for examination: 7-10 mg / kg body weight.
  • For minor surgery with short anesthesia: 10-15 mg / kg body weight.
  • Intramuscularly in cats – for examination or minor surgery: 10 mg / kg body weight.
  • Intravenously in dogs – for examination: 5 mg / kg body weight.
  • For minor surgery, short anesthesia: 7.5 mg / kg body weight.
  • Intravenously in cats – for examination, minor surgery: 5 mg / kg body weight.

There is no cumulative effect, and it can be reinjected. Additional doses should be smaller than the initial dose (1/3 to 1/2 of the initial dose). The total injected dose (initial + additional doses) should not exceed the maximum safe dose of 30 mg / kg body weight in dogs and 72 mg / kg body weight in cats (lethal dose 100 mg / kg intramuscularly in both species). The dose varies in wild animals.

Duration of Anesthesia:
20-60 minutes, depending on the dosage.

Analgesia has a longer duration than surgical anesthesia. The return to normal is gradual (2-6 hours), provided noise and light are avoided. Recovery may be longer in case of overdose in obese or old animals.

Side Effects:
Sometimes salivation is observed, which is controlled by administering anticholinergic drugs such as atropine before anesthesia. Reduce the dose when using other anesthetics.


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