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COMPOSITION Tylosin tartrate, equivalent to tylosin 0.2 g Excipients up to 1.0 ml PHARMACOLOGICAL ACTION: Tylosin is a macrolide antibiotic with a bacteriostatic effect against Gram-positive and some Gramnegative microorganisms – cocci, Corynebacterium, Clostridium, Serpulina (Spirochaeta), Vibrio, Leptospira, Brucella, Neisseria, Haemophilus, large viruses, Chlamydia, including also some anaerobic microorganisms, etc. It is highly effective against Mycoplasma. Applied intramuscularly, the antibiotic is quickly resorbed reaching maximal concentration in blood one hour after the injection. During the first 8 hours blood levels are higher than these reached after treatment with the preparation Tylovet B-200 (applied at the same doses). Excretion is mainly through urine and bile (the feces respectively), with milk in lactating animals, and also with sperm in brood animals. It is compatible with tetracycline, sulfanilamides, erythromycin and spectinomycin. Its solution is sensitive to light (disintegration occurs). INDICATIONS Respiratory diseases in large and small ruminants, pigs, dogs (rhinitis, tonsillitis, laryngitis, bronchitis, pneumonia, etc.); necrotic enteritis, erythema, enzootic bronchopneumonia, dysentery in pigs; mastitis and endometritis, infectious agalactia in sheep and goats; arthritis of mycoplasmic origin; vibriosis in cows and sheep; panaritium, otitis, and infected wounds; leptospirosis; infectious conjunctivitis in calves and cows. CONTRAINDICATIONS The product must not be applied to horses, rabbits, guinea pigs, hamsters as well as in newly-born animals. MODE OF ADMINISTRATION Intramuscularly! Do not apply more than 10 ml at one site. DOSAGE Animal species Tylovet – 200 inj. solution Large ruminants Calves Sheep and goats Pigs Dogs 3.0 – 5.0 ml/100 kg b.w. 2.5 ml/50 kg b.w. 3.0 ml/50 kg b.w. 2.5 ml/50 kg b.w. 0.5 – 2 ml / 10 kg b.w. The preparation must be administered once daily for 3 5 days. WITHDRAWAL PERIOD For meat and milk – 5 days after the administration of the preparation. STORAGE In the original container, well closed, in dry facilities, protected from direct sunlight at temperature between 8 and 15°C. SHELF LIFE Eighteen (18) months from the date of manufacture.